Metabolic & Chronic Disease

APOL1-Mediated Kidney Disease

Last reviewed: October 2026

Variants of the APOL1 gene, found in people of recent African ancestry, raise the risk of several kinds of kidney disease. They probably became common because carrying one copy protects against African sleeping sickness.

Warning Signs

Often silent until advanced
Swelling
Foamy urine
Fatigue

Prevention Tips

Genetic counselling if kidney disease runs in your family
Regular kidney function tests
Keep blood pressure under control

Where to get checked or find care for APOL1-mediated kidney disease in your country.

Find Screening & Care

Sources

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Medical disclaimer: This information is for education and community awareness only. It is not medical advice, diagnosis or treatment. Always talk to a qualified healthcare provider about your health, and call emergency services if you think someone needs urgent help.