Cardiovascular

Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Last reviewed: October 2026

An inherited heart condition in which abnormal protein builds up and stiffens the heart muscle. The heart form is more common in people of African ancestry: it is estimated to affect 3 to 3.9% of African Americans and about 5% of people in some parts of West Africa.

Warning Signs

Shortness of breath with mild activity
Swelling in the legs or ankles
Irregular heartbeat
Fatigue

Prevention Tips

Genetic counselling if heart failure runs in your family
Early heart check-up for unexplained shortness of breath or swelling
Regular checkups

Where to get checked or find care for transthyretin amyloid cardiomyopathy (ATTR-CM) in your country.

Find Screening & Care

Sources

Transthyretin amyloidosis — MedlinePlus Genetics, NIH

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Medical disclaimer: This information is for education and community awareness only. It is not medical advice, diagnosis or treatment. Always talk to a qualified healthcare provider about your health, and call emergency services if you think someone needs urgent help.